In recent years, scientific evidence has developed to support the use of resveratrol in nutritional supplements to promote healthy aging, including the management of arthritis, metabolic bone disease, and osteoporosis. Numerous studies have demonstrated that trans-Resveratrol (resveratrol) dramatically modulates indicators of bone metabolism.
Resveratrol Boosts Bone Density for Postmenopausal Women
Another study in 2005 identified the effect of trans-resveratrol on bone metabolism in rats that had been ovariectomized. 48 rats were divided into different groups with resveratrol supplementation added for one group. The trans-resveratrol-supplemented group had a higher bone mineral density (BMD) on the 90th day than the other groups. All of these findings suggest that resveratrol may have a protective effect against postmenopausal osteoporosis.
Resveratrol Increased Plasma Levels & Bone Metabolism
Research utilizing lower dosages of resveratrol showed that 16 weeks of resveratrol supplementation enhanced plasma levels of bone metabolism biomarkers and improved the lumbar spine bone mineral density in a dose-dependent manner when compared to the placebo group. In contrast to other supplements commonly used to treat bone loss, such as vitamin D and calcium, resveratrol’s bone health benefits may be mediated through an increase in the number and activity of osteoblasts (bone-forming cells), rather than through a decrease in the activity of osteoclasts (bone-resorbing cells).