Bone Loss and Trans-resveratrol Supplement

June 21, 2020

In recent years, scientific evidence has developed to support the use of resveratrol in nutritional supplements to promote healthy aging, including the management of arthritis, metabolic bone disease, and osteoporosis. Numerous studies have demonstrated that trans-Resveratrol (resveratrol) dramatically modulates indicators of bone metabolism.

Resveratrol Boosts Bone Density for Postmenopausal Women

According to studies published in the Journal of Bone and Mineral Research, a naturally occurring polyphenol found in red grapes and berries may give a preventive advantage for reducing bone loss in postmenopausal women without osteoporosis. Find out more about this polyphenol here.

In a recent clinical trial, 128 postmenopausal women without hormone treatment women were given either 75 mg resveratrol or a placebo twice daily. After 12 months, participants switched to the alternate therapy or placebo. DXA was used to measure bone density in the lumbar spine, whole hip, and femoral neck at baseline and post-treatment. The bone density of the lumbar spine was increased to 1.3%.

Another study in 2005 identified the effect of trans-resveratrol on bone metabolism in rats that had been ovariectomized. 48 rats were divided into different groups with resveratrol supplementation added for one group. The trans-resveratrol-supplemented group had a higher bone mineral density (BMD) on the 90th day than the other groups. All of these findings suggest that resveratrol may have a protective effect against postmenopausal osteoporosis.

Resveratrol Increased Plasma Levels & Bone Metabolism

Research utilizing lower dosages of resveratrol showed that 16 weeks of resveratrol supplementation enhanced plasma levels of bone metabolism biomarkers and improved the lumbar spine bone mineral density in a dose-dependent manner when compared to the placebo group. In contrast to other supplements commonly used to treat bone loss, such as vitamin D and calcium, resveratrol’s bone health benefits may be mediated through an increase in the number and activity of osteoblasts (bone-forming cells), rather than through a decrease in the activity of osteoclasts (bone-resorbing cells).

Effect on Bone Health With Diabetes

Patients with type 2 diabetes (T2DM) have a higher risk of fracture than other patients. A study on the effect of resveratrol on bone mineral density (BMD) and calcium metabolism biomarkers in individuals with type 2 diabetes mellitus. For six months, 192 Type 2 diabetes outpatients were randomly assigned to receive resveratrol 500 mg/day, resveratrol 40 mg/day, or placebo. At baseline and six months, the results showed that 500 mg resveratrol supplementation protected bone density decrease in individuals with Type 2 diabetes mellitus, particularly those with adverse baseline circumstances.