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Check out Science for the latest research findings on Spermidine and on longevity!

SPD Spermidine FAQ

Why do we need to boost SPD spermidine levels?

Spermidine (SPD) is a powerful polyamine renowned for promoting autophagy, the cellular regeneration and recycling mechanism of the body that decreases with age. As you age, your body produces less spermidine, making it tougher for cells to activate autophagy and prevent age-related decline. 

Restoring spermidine to its youth levels has had astounding effects such as the below (research summary)as shown in many clinical researches:  

1. Longevity
2. Boost stress tolerance
3. Improves cardiovascular function
4. Enhances fertility
5. A Neuroprotective agent
6. Cancer prevention
7. Reduces age related complications 
8. Enhances function of hair follicles

What are the side effects of SPD spermidine?

Because spermidine occurs naturally in the human body, it is believed to be fully safe. Researches have proven that the supplement has no negative side effects. 

In accordance with Section 20l(s) of the Federal Food, Drug, and Cosmetic Act, the FDA has determined that spermidine-rich wheat germ extract is Generally Recognized As Safe (GRAS). 

What is the suggested dosage of SPD spermidine? How much does Harvard Professor Dr. David Sinclair take?

Spermidine is a powerful compound that stimulates autophagy and also have stabilizing effects on the epigenome. The highest dose tested in humans was 6mg once daily, and that was in a single study. Up until now, 1-6mg of spermidine per day has been the standard for the majority of investigations.

Professor of anti-aging genetics at Harvard, Dr. David Sinclair, stated in a recent interview that he takes 1 mg of spermidine on a regular basis

Spermidine for hair growth. The study indicated that spermidine supplementation of 0.5 mg can support hair growth and strength. 

Spermidine for cardiovascular health. According to a research, use of spermidine supplement of 4 mg/daily for 8 weeks reduces the risk of hypertension, heart failure, and other cardiovascular issues.

Spermidine to support cognitive function. A study indicates that the dosage of 1.2 mg of spermidine for 3 months reduced age-related cognitive decline and risk of Alzheimer’s. 

Spermidine to slow down aging. One study found a connection between higher spermidine consumption from dietary sources such as supplements and improved human survival rates.

Spermidine for post covid vaccination. Another current human study uses proven ways to investigate if older people may safely take a daily spermidine supplement after having a SARS-CoV-2 booster injection.

Check out this article for dosing advice. 

How to take SPD spermidine? What is the suggested usage of SPD spermidine?

Spermidine is most effective when taken in the morning at the same time every day and recommended to ingest along with food to enhance their absorption .

As a David Sinclair, the longevity genetic expert and Harvard professor, takes spermidine in the morning. 

Can we obtain enough SPD spermidine from food? What are the food sources of SPD spermidine?

Although about 1/3 spermidine may be synthesised endogenously in humans , only a negligible amount actually does so. The remaining amount must be obtained from food. 

It can be found in food items including , wheat germ, cheese, mushrooms, soy products, legumes, corn, and whole grains. Learn more about how much in each food in this article

In contrast, the concentration of spermidine in these natural sources is 1%, 2%, or even lower. Hence, if you wish to enhance your SPD spermidine levels, Rescence our premium spermidine dietary supplement is the ideal option. 

Where is Rescence Pure Spermidine sourced or manufactured?

Laboratories and blending facilities can be located anywhere in the world but quality spermidine with stringent quality control are primarily sourced in areas where wheat germ production is abundant particularly China.

Our laboratory is located in Hong Kong with minimum travelling distance from the source to manufacture ensuring the freshness of product while minimizing carbon footprint.

How to tell if the SPD spermidine supplement is pure?

Natural spermidine supplement is often extract of wheat germ. The color can range from light yellow to brown as the wheat germ’s natural color and often in 0.1% or 0.2% concentration. Rescence Pure SPD Spermidine 15000 is of high concentration of 1%, meaning 500 mg renders 5 mg SPD spermidine.

In addition, a solid and trustworthy supplier would have the certification to prove the ingredient is free of toxins by internationally recognized testing bodies such as SGS.

Even while your body’s natural autophagy mechanism is at its peak in the early twenties, people may start using spermidine supplementation to further boost autophagy without negatively impacting the metabolism from late twenties onwards.

Why is Rescence Pure Spermidine in beige powder form?

Supplemental spermidine is typically derived from wheat germ and is available in powder or capsule form. Spermidine-rich wheat germ extract appears as a beige to brown powder. 

Users can have the flexibility of adjusting the dosage depending on their preferences. See more about dosage in this article.

How to store Rescence Pure Spermidine at home?

Rescence Pure SPD Spermidine should be stored tightly inside an opaque container, avoiding direct sunlight, in a cool and dry place below 25°C / 77°F for up to 24 months.

What are the drug interactions of SPD spermidine?

Since spermidine is a natural supplement, it has been found safe for overall consumptions. Drug interactions are detailed here

Gluten allergy or gluten sensitive users may need to pay caution when ingesting Rescence Pure SPD Spermidine 15000 as supplement is extract of wheat germ.

Always consult a medical professional when adding or subtracting any food, supplement or medication. 

Several points are important when choosing a spermidine supplement:

1. Whether the spermidine content in mg is clarified per pack or per capsule and without counting other ingredients.

2. Whether the total content of spermidine matches what is claimed on the packaging. 

3. Whether the product is made in a GMP certified facility and not certified by unknown laboratory.

4. Whether the product quality is stable, the longer the expiration date, the more stable the quality is tested for.  

7. Whether it’s in powder form and in beige to brown color. 

8. Whether the packaging is light-proof and not in a transparent bottle or pack.

9. Whether the purity is clarified as the top standard of at least 1% and not anything less 0.3% nor the impossible 100%.

Does Rescence have GMP Good Manufacturing Practice certification?

Yes. Rescence Laboratory manufactures to the guidelines of good manufacturing practices (GMP) , ISO 22000, HACCP and CODEX certified by SGS. 


Does Rescence conduct toxin and microbiological tests on the products?

Yes. Rescence Laboratory commissions a third party, word’s leading testing body SGS, to perform quality control tests assuring product quality and safety. 


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