Reverse senescence through science

In general, if a person consumes resveratrol in small doses over a short period of time, they will not suffer any negative effects. However, with daily dosages of 2.5 g or more, the following adverse effects may occur:

• Nausea
• Vomiting
• Diarrhea
• Liver dysfunction
• Renal toxicity at 3000 mg per day in rats

One participant in a 2016 study got fever and cytopenia (low blood cell count) when consuming 1.5 g resveratrol per day for 6 months.

When taken orally: Resveratrol is commonly found in modest levels in foods. When used orally in quantities of up to 1500 mg daily for up to three months, resveratrol supplements may be safe. For 2-6 months, higher dosages of up to 2000-3000 mg daily have been used successfully. These greater dosages, however, are more likely to induce gastrointestinal trouble.

Skin Application: Resveratrol may be safe to take for up to 30 days.

Nasal Spray: Resveratrol is possibly safe when used for up to 4 weeks.

In those with bleeding problems, resveratrol may decrease blood coagulation and increase the risk of bleeding.

Resveratrol has the potential to mimic estrogen. If anyone has a disease that might be exacerbated by estrogen exposure like breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids, they avoid using resveratrol. Women having a history of estrogen-sensitive malignancies, such as breast, ovarian, and uterine cancers, should avoid resveratrol supplements until more is known about its estrogenic effect in humans.

The below list shows the dosages used in recent human trials:

Oral intake of 25 mg of resveratrol revealed that it has extremely low bioavailability.

75 mg was given to type 2 diabetes patients with improved neurovascular coupling capacity and improved cognitive performance.

270 mg was given to overweight, obese or postmenopausal people with improved flow-mediated dilatation.

80 mg and 282 mg were given to overweight or obese subjects with improvement in mitochondrial capacity, fat oxidation stimulation.

250-500 mg of trans-resveratrol showed improvement in cerebral blood flow in healthy subjects.

In a meta-analysis of the effects of resveratrol on glucose control and insulin sensitivity, doses ranging from 8 to 1,500 mg/day and durations ranging from 2 weeks to 6 months were used; these studies included patients with type 2 diabetes mellitus, cardiovascular disease, obesity, or metabolic syndrome, as well as healthy volunteers.

Resveratrol at a high dose (1,000 mg twice daily) was administered for up to one year in patients with mild to severe Alzheimer’s disease and 500 mg three times daily for six months in individuals with non-alcoholic fatty liver disease. The first dose for exercise capacity was 500 mg twice daily for one week, followed by 1,000 mg twice daily for the remaining three weeks.

A continuous intake of moderate dosage 450 mg – 1000 mg / 1 g renders positive health effects associated with oxidative stress and inflammation.

5,000 mg / 5g of resveratrol was given to patients of Friedreich ataxia for 12 weeks showing improvement in neurologic function, audiology and speech measures as well as oxidative stress marker plasma.

500 mg, 1000 mg, 2,500 mg, and 5,000 mg were given to 40 healthy volunteers for 29 days resulting in a reduction of cancer risk. The highest reduction was observed with a 2,500 mg / 2.5 g dosage.

People have varying tolerances for resveratrol, and there is no universally advised amount. People should see their physician determine the dose that is both safe and useful for their body.

Bioavailability of resveratrol is higher on an empty stomach (8 hours of fasting) and when taken in the morning due to the influence of the circadian rhythm.

Dr. David Sinclair, the longevity genetic expert and Harvard professor, has been using NMN over a decade. He dissolves the white powder form of NMN and resveratrol in either Greek yogurt or organic cold press olive oil before ingestion every morning.

Resveratrol requires the fat source to ingest along hence the dissolution in Greek yogurt or in olive oil prior to oral intake.