NMN products often shown with a specific number: NMN 6000, NMN 9000, NMN 10000, NMN 15000 or NMN 18000. For Rescence, Pure NMN 15000 and Pure Resveratrol 15000 represent the exact strength of the active ingredient NMN (99% purity) or trans-resveratrol (98% purity) in each product. As both are in pure powder form, 15000 means 15000 mg of NMN and 15000 mg of trans-resveratrol (1 g = 1,000 mg).
Consumers should be aware that this is not applicable for all brands. Some brands may not show how much milligram of resveratrol or NMN in each capsule due to minimal content and some would add up the milligrams of multiple ingredients to package under NMN 18000 for example. while the actual strength of NMN is less than what is made believe.
At Rescence, we value integrity. We recommend that whether it’s for supplements or food, always check the label to see no inferior ingredient is mixed in to support your wonderful longevity journey!
Why do we need to boost NAD+ or take NMN?
The NAD+ levels drop to 50% of our youth by middle age.
Nicotinamide adenine dinucleotide (NAD+) is an essential molecule with crucial roles in over 400 metabolic reactions. We can maintain and boost healthy levels of NAD+ contributing to the below benefits by using nicotinamide mononucleotide (NMN):
2. Mitigates Physiological Aging
3. Enhances Vascular Health and Circulation
4. Helps to repair DNA
5. Guards against Heart Disease
6. Supports Neurological Functioning
7. Upholds Metabolism
8. Improve Stem Cell Health
9. Enhances Muscular Strength
10. Regulates Body Fat
Find out details of the above stated NMN benefits in this in-depth research summary.
What are the side effects of NMN?
NMN supplement was shown safe without any side effect with up to 1200 mg per day for 6 weeks – 10 male and 2 female amateur runners between 27 and 50 years old, reported no obvious side effect.
People who have used NMN supplements have not yet experienced any substantial negative side effects of taking NMN, which is a positive development.
Not enough studies are conducted on humans in preventing or suppressing cancer cells. It is always advised to consult physicians prior to taking any supplements.
What is the suggested dosage of NMN? How much does Harvard Professor Dr. David Sinclair take?
The suggested dose for adults between the ages of 30 and 60, based on the results of effectiveness and safety studies in humans and animals, as well as calculations of optimal NMN doses, is 500 mg per day. People over the age of 65 can safely take 750 mg of NMN per day to get the most out of the supplement.
NMN to Support Skin Health: Study indicated that 250–300 mg of NMN per day may help protect and heal sun-damaged skin.
NMN to Improve Muscular Function: A study found that taking 250 mg of NMN daily for 12 weeks improves muscular function in males over 65. The same dosage for 10 weeks also showed an increment in insulin sensitivity and women’s muscles.
NMN to Uphold Cardiovascular Health: Researchers are conducting a clinical trial to determine the effect of NMN on cardiovascular and metabolic health when given 250 mg daily.
NMN to Support Fertility: A study demonstrated that a low dose of 350 mg per day in a 50 kg person NMN restored fertility, more than 1,400 mg per day did not demonstrate benefit, suggesting an appropriate human dosage is between 350 mg to 1,500 mg per day.
NMN to Boost Metabolism: According to the results of scientific research , 1,000 mg of oral NMN supplement per day can enhance NAD+ metabolism in healthy middle-aged and older individuals.
Renowned anti-aging genetic research Harvard professor Dr. David Sinclair has said in a recent interview that he himself takes powder form 1,000 mg of NMN daily in addition to 1,000 mg of resveratrol without seeing any harmful effects for over a decade.
NMN’s safety and efficacy are also being investigated in other clinical trials registered with the World Health Organization (WHO).
There are no definitive studies demonstrating that NMN has adverse effects at regularly used levels (up to 1,000 mg per day), and the elevated NAM associated with such concentrations is unlikely to pose a substantial health concern.
It is prudent to avoid doses of more than 1,000 mg per day if using oral capsules, as these dosages result in significant increases in NAM and may create methylation problems for certain individuals.
How to take NMN? What is the suggested usage of NMN?
NMN is most effective when taken in the morning and can be ingested with water or food. NMN, boosting NAD+, has an impact on the circadian rhythm – the ingestion of NMN supplement should happen during the day and within six hours after being awake.
As a David Sinclair, the longevity genetic expert and Harvard professor, has been using NMN over a decade. He dissolves the white powder form of NMN and resveratrol in either Greek yogurt or organic cold press olive oil before ingestion every morning.
Rescence Laboratory team unanimously prefers a tasty savory treat dissolving the Rescence Pure NMN and Pure Resveratrol in a teaspoon of organic cold press olive oil and a bit of balsamic vinegar first thing in the morning, in their salad (for those who are not doing intermittent fasting!)
Can we obtain enough NMN from food? What are the food sources of NMN?
Most NMN is synthesized from vitamin B3 in the form of nicotinamide in mammals. Although small amounts of NMN are naturally found in fruits and vegetables such as avocados, broccoli, cabbage, edamame, and cucumbers. As it requires substantial NMN to render a NAD+ boosting effect (such as 1,000 mg), it is therefore too minimal to consume sufficient amount to be reversing the senescence of aging.
Where are the differences between NR and NMN?
Studies have been conducted for both NR and NMN in boosting NAD+. According to the Harvard’s genetics professor David Sinclair’s interview, he supplements with NMN rather than NR as in experiment, NMN makes older mice run further by +50% as a result of improved blood flow and energy. Supplementing with NR at the same dose didn’t replicate a positive result as comparing to NMN. Read this article for more details on the differences.
Where is Rescence Pure NMN sourced or manufactured?
Laboratories and blending facilities can be located anywhere in the world but quality NMN with stringent quality control are primarily sourced in China and some from Japan due to the patented preparation methods. Consumers should be weary of fraud if any claim about NMN sourced outside Asia.
Our laboratory is located in Hong Kong with minimum travelling distance from the source to manufacture ensuring the freshness of product while minimizing carbon footprint.
How to tell if the NMN is pure?
Pure NMN is in white powder form, without any artificial colors, rather than the more commonly found often encapsulated beige to brown color. NMN is light sensitive; slightly off white can be due to an overexposure of light and/or high temperature for a duration of time.
Pure NMN in white powder form is hard to come by due to the high production costs. Often times, capsuled supplements may mix in other ingredients which would include fewer milligrams of NMN.
In addition, a solid and trustworthy supplier would have the certification to prove the ingredient is free of toxins by internationally recognized testing bodies such as SGS.
Why is Rescence Pure NMN in white powder form?
Rescence offers NMN in white powder form for the below reasons:
– The size of capsule to contain 1000 mg potency of NMN would be too large to swallow which can discourage regular usage and potentially cause choking hazard.
– NMN’s purest form is white powder, users can easily incorporate the white powder in their meals or drinks.
– Users can have the flexibility of adjusting the dosage depending on their preferences. See more about dosage in this article.
– Quality is better preserved in powder than in liquid form to avoid accelerated degradation.
– It helps to minimize the risk of ingesting gelatin contaminated of animal diseases
Why is Rescence Pure NMN product of 1,000 mg, with such high potent strength?
Given the latest research findings for NMN, 1,000 mg of NMN would render healthy aging effects versus products of lower potency. The flexibility of powder form allows ingesting 1,000 mg based on the product weight of 1,000 mg.
Why is it rare to find potent strength of NMN?
Most NMN suppliers tend to compete on pricing by offering diluted potency of NMN while mixing in less expensive ingredients to the capsule. Most NMN capsules available in the market yield between 50mg to 150mg per capsule.
Consumers are recommended to be mindful about the costs if they are to ingest the equivalence of 1,000 mg of effective NMN to achieve their longevity goal. For Rescence Pure NMN, simply weigh the product for 1,000 mg to ingest 1,000 mg of NMN which is also the approximate equivalence of 4 provided scoops.
How to store Rescence Pure NMN at home?
NMN is light sensitive, and when left exposed to light they can degrade and turn darker to brown thus rendering diminished functioning.
Pure NMN should be stored tightly inside an opaque container, avoiding direct sunlight, in a cool and dry place below 25°C / 77°F for up to 12 months, below -15°C / 5°F for up to 36 months, in the freezer or refrigerator after opening.
Why Rescence Pure NMN nutraceutical supplement’s expiration period is 36 months?
The expiration period of Rescence Pure NMN can reach 36 months upon manufacture if stored without direct sunlight in a dry place below -15°C / 5°F.
Stability tests have confirmed that Rescence Pure NMN can sustain at or above 99% purity over 36 months without degradation – this demonstrates a superb stability and quality.
What are the drug interactions of NMN?
There is no known drug interactions of NMN at this moment.
Several points are important when considering a NAD+ booster supplement for you:
1. Whether it’s NMN or NR (Tru Niagen is NR) – see more on the comparison here.
2. Whether the NMN content in mg is clarified per capsule and without counting other ingredients
3. Whether the total content of NMN matches what is claimed on the packaging, eg. 15000 is really 15000 mg of NMN
4. Whether the product is made in a GMP certified facility and not certified by unknown laboratory
5. Whether the product quality is stable, the longer the expiration date, the more stable the quality is tested for
6. Whether it’s in powder form and in white (do not consume if it’s not pure white color as it could degrade or be contaminated)
7. Whether the packaging is light-proof and not in a transparent bottle or pack due to NMN’s sensitivity to light
8. Whether the purity is clarified as the top standard of at least 99% and not anything less nor the impossible 100%
Does Rescence have GMP Good Manufacturing Practice certification?
Yes. Rescence Laboratory manufactures to the guidelines of good manufacturing practices (GMP) , ISO 22000, HACCP and CODEX certified by SGS.
Does Rescence conduct toxin and microbiological tests on the products?
Yes. Rescence Laboratory commissions a third party, word’s leading testing body SGS, to perform quality control tests assuring product quality and safety.