The use of NMN has been shown to be effective in the prevention of age-associated weight gain, the enhancement of energy metabolism and physical activity, the improvement of insulin sensitivity and eye function, the improvement of mitochondrial metabolism, and the prevention of age-linked changes in gene expression. Experts think that the use of NMN is one of the most efficient techniques of enhancing NAD production in the body. What are the long-term advantages of NMN over physical activity?
NMN Improves Exercise Endurance in Runners
Hu and colleagues from Guangzhou Sport University published a human experiment in the Journal of the International Society of Sports Nutrition demonstrating that NMN powder taken orally can boost adult runners’ aerobic capacity – the amount of oxygen consumed by the muscles. Hu and colleagues gave runners 300, 600, or 1200 mg/day of NMN powder orally for six weeks to see if they got the same advantages.
Cardiopulmonary exercise testing was performed after each of the three dosage groups had exercised for 40-60 minutes, five to six times per week, for a total of five to six weeks. The findings that NMN and training boost the oxygen consumption of middle-aged runners suggest that NMN supplements should be included in exercise regimens for this age group. This has the potential to improve training performance and endurance.
12 Weeks of NMN Improves Muscle Function
Research Square just released a peer-reviewed journal paper by Yamauchi and colleagues from the University of Tokyo, revealing that oral administration of 250 mg of NMN daily significantly increased NAD+ levels and improved muscular performance in males over the age of 65.
The use of NMN significantly boosted important physical strength and performance measures, such as walking speed, grip strength, and the number of times an individual could get out of a chair in 30 seconds. As a result, it has been demonstrated that oral supplementation with 250 mg NMN per day is a safe, well-tolerated, and effective approach to enhancing NAD+ metabolism in healthy older males.
NMN Enhances Aerobic Capacity
Treatment with Nicotinamide Mononucleotide (NMN) for six weeks, according to a human study published on July 8, 2021, dramatically enhanced the ventilatory threshold (VT) in amateur runners. The use of NMN tablets in conjunction with physical activity increased the ventilatory threshold. Ventilation rises in tandem with the intensity of the activity. The ventilatory threshold rises as a result of increased endurance or athletic ability, for example. However, these advantages were limited to skeletal muscle and did not result in an increase in the heart’s aerobic capacity. A dose-dependent benefit was seen, which was connected with muscle.
Blood Vessel Growth Via NMN.
Endothelial cells are essential for the development of new blood vessels, which transport oxygen and nutrients to organs and tissues throughout the body. The opposite occurs as endothelial cells age: blood vessels shrink, new blood vessels fail to grow, and blood flow to the majority of organs is reduced. To function properly, skeletal muscle, which is highly vascularized, requires an adequate amount of oxygen and nutrients. They shrink in size when their supply of nutrients is reduced, resulting in a condition known as sarcopenia. Research in mice was carried out with the use of NMN supplementation. After two months of NMN treatment, the skeletal muscles of old mice developed new blood vessels.
