New SARS-CoV-2 (covid-19) has been responsible for the worldwide outbreak in 2019 (COVID-19). Many Covid-19 sufferers were on the verge of death due to respiratory problems, including pneumonia and lengthy hospital stays. Despite very effective vaccinations, the rapid mutation of SARS-CoV-2 has created a great deal of uncertainty in the COVID-19 pandemic, prompting the development of medications specifically for treating Covid-19.
NAD+ deficiency has been linked to worsening COVID-19 symptoms such as pneumonia, which can also lead to respiratory distress and eventually death. Therefore, increasing the metabolite levels in at-risk groups might be an effective treatment option in this regard. An easy strategy to increase NAD+ levels is supplementing the diet with more precursors for NAD+ synthesis.
Study Revealed NMN Effects on Pneumonia Associated with Covid-19.
A study published in April 2022 in the journal Nature.com suggests that NMN may help individuals recover from the effects of the virus.
The researchers looked at how SARS-CoV-2 infection affected lungs and associated pneumonia and examined if NAD+ and the intermediate NMN had any protective effects in the lungs of two separate mice models of disease with SARS-CoV-2. These chosen categories of mice were selected because of a symptom of severity. Also, the mice were chosen as the model mimicked several gene expression alterations and the activation of different immunological pathways for pneumonia in human samples in older studies of this genre. The MASCp6 and MASCp36 Covid strains were used for this trial.
NMN Reduced Inflammatory Damage.
To examine if NAD+ supplementation using NMN might reverse pneumonia caused by Covid 19 by reducing the inflammatory damage it creates in the lungs. The team administered NAD+ 1 mg/g/day intraperitoneally (via peritoneum) for three days to elderly (8–9-month-old) and young (6–7-week-old) infected female mice using the same route as the older ones. Upon analysis, it was discovered that the number of macrophages dramatically decreased in old and young mice treated with NAD+. Thus, in both old and young animals, NAD+ supplementation protects the lung against inflammatory damage induced by SARS-Cov-2 infection but does not cause reduced viral replication of Covid 19. It was also studied that NAD+ supplementation partly reverses the gene expression modifications induced by SARS-CoV-2 infection.
NMN Inhibited Cell Death.
In a severe viral scenario, mice were infected with a SARS-CoV-2 mouse model to see if NAD+ intermediates have comparable therapeutic effects on covid-induced pneumonia. Aged 8–9 months, infected mice were treated with NMN or NAD+. According to body surface area, the dose of NMN (0.5-1mg/kg/day) often utilized in mice models is equivalent to 55 mg/kg/day in humans. Cell death even after infection was reduced in the NMN group. More notably, 30% of the mice in the NMN group survived, but 100% of the mice in the saline group died. Many of the findings from the research were corroborated by PCR data, and NAD+ supplementation helped to maintain the NAD+ maintaining system.
In addition, significant inflammatory cell infiltration and cell death brought on by SARS-CoV-2 infection may be reversed by NAD+ therapy by inhibiting the expression of Cd200r3, Cd200r4, and Apaf1, as well as other untested linked genes. Another finding of this study was this supplementation partly ameliorates the metabolic disruption produced by SARS-CoV-2 infection.
In conclusion, for Covid-19, NAD+, an emerging regulator of immune responses during viral infections, may be an attractive treatment target. This article says boosting NAD+ levels may improve antiviral protection and reduce uncontrolled inflammation in mice models. They also concluded that increasing NAD levels with NMN was so beneficial that human trials should be undertaken for patients with the virus. If you have any questions about your health and NMN, it is always advised to see a qualified medical professional.