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Dosage of Spermidine and Its Effect for Maximum Health Benefits.

spermidine health benefits

Without a doubt, spermidine is an extraordinary molecule. It makes people healthier, allows them to live longer, and helps them seem younger. Because of a natural decline in the levels associated with aging, we age more rapidly.

Why Spermidine?

As you age, many of your body’s cells become senescent. This is bad news since senescent cells generate many negative substances that lead other cells in their area to become unhealthy. This indicates that they are not supporting the tissue in which they reside and are not dividing to produce new healthy cells.

This results in a decline in the function of your tissues and an increase in inflammatory processes, which leads to the numerous age-related disorders the aging population currently faces.

Researchers have observed almost no decline in senescent cells in younger populations, but after 40 to 50 years, these numbers increase at an alarming and compounding rate. This all can be delayed and halted with the use of spermidine supplementation.

High concentrations of spermidine have been shown to slow the aging process in cells and maintain their health throughout time, lending credence to the claim that the substance is a potent “elixir of life.”

This article will look at the remarkable effects and dosage of spermidine supplementation, especially in humans.

It is found in every part of the human body and comes from three distinct sources.

  • Endogenous spermidine is made from the precursor amino acid ornithine
  • Microbial spermidine, produced from gut microbe
  • Dietary spermidine is obtained from food.

The need for exogenous spermidine in the diet increase with age since both endogenous production and use reduce with time.

Spermidine for Hair Health

This has been clear since 1997 when researchers revealed the crucial role polyamines play in hair follicle function/growth and fiber composition.

Spermidine potentially increases keratin production, promoting new hair growth and preventing hair loss.

Researchers found that spermidine affected every part of the development of a human hair follicle, including how keratin was expressed, how it grew, how it cycled, and how epithelial progenitor cells worked. Additionally, it has been shown to moderately promote the human hair matrix. The dosage used in this research was 0.1–1 µM (micromole), translating into 0.001mg. 

The result of another study suggests that spermidine could be used to treat premature greying of the hair by making more melanocytes in the body. 

Skin Health

Human research has shown that spermidine can also slow skin aging with a dosage of 0.8mg. The Streptococcus bacterium secretes spermidine, which stimulates the formation of collagen, elastin, and lipids in aged skin cells, enhancing the skin’s structural integrity and barrier function.

Adding spermidine tablets to your daily routine will help you access internal antiaging benefits and boost your health in all aspects.

Cardiovascular Health

Researchers have found that spermidine can slow the deterioration of cardiovascular function by 10% in mice models. It can translate to an average of eight additional years of life expectancy in humans.

Additionally, animal studies indicate that spermidine enhances the survivability of cardiac muscle cells following a heart attack.

In another study, it works like an anticoagulant similar to aspirin but with relatively fewer side effects. It works by inhibiting the EP300 gene providing further cardioprotective benefits.

Authors from the United States’ famous National Institute of Health (NIH) recommended increasing dietary and supplemental spermidine.


There is a correlation between our blood spermidine levels and our ultimate health and mortality. Supplementing with spermidine has been shown to extend life in various model species, including mice, for over ten years. Multiple experiments have demonstrated a 25% increase in lifespan and health span. (1)(2)(3)

Increased spermidine levels provide greater protection against degenerative diseases and the mortality that comes with aging. Two separate human investigations have demonstrated this. (2) A 2022 study published in the American Journal of Clinical Nutrition indicated that a higher spermidine intake is connected with a reduced mortality risk. 

Some of the world’s longest-lived people consume it in large amounts as part of their diets. 


Cognitive Function

A year-long study in 2022 on its supplementation showed that 0.9mg of dosage didn’t affect mental improvement.

After three months of supplementation with 1.2 mg of spermidine per day, older adults with cognitive deterioration did not demonstrate any improvement. But it proved that the supplement was well-tolerated and safe.

But an Austrian research from 2021 suggests that spermidine may potentially boost brain capacity with the intake of 3.3mg of spermidine daily. According to the study’s authors, increased spermidine intake was associated with enhanced general cognitive performance and spatial and temporal memory. Memory loss in elderly people at risk for dementia was reduced by spermidine in the same study.

As a result, spermidine’s promise as a new treatment method against aging may be more easily supported by the fact that most people may be able to obtain its benefits through dietary alterations or supplements with little effort. This is one of the most promising new anti-aging compounds, and the science behind it is excellent.


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