Does NAD have any effect on skin health?
While many individuals like some sun, they are aware of the dangers of absorbing too many rays. UV light exposure may damage DNA directly, stimulate the creation of harmful chemicals called reactive oxygen species in cells, trigger local inflammation, and deplete cellular energy, all of which can result in cell death. Scientists may have discovered a viable remedy in the form of NAD+.
- Topical. The systemic and topical use of niacinamide has been shown to be beneficial in the treatment of medical and esthetic disorders.
- Skin Aging.
- Wound Healing. NAD- usage reduced the time required for wound healing from 15–17 days to 7–10 days, which was found to be achievable.
- It is anti-inflammatory. After 8 weeks, 82 percent of those treated with NAD had improved overall clinical condition.
- Hyperpigmentation. Niacinamide skin lightening has been shown to cause significant lightening of hyperpigmentation in some cases.
- Rosacea. There was a reduction in the reddening of the skin, which was associated with an improvement in the horny layer moisture.
2. NAD+ Protects Against UV Damage.
- Skin NAD+ deficit causes UV sensitivity, DNA damage, and wrinkles by decreasing the dermis-epidermis link in extrinsically aged skin. NAD+ may help maintain a healthy dermal matrix by suppressing collagen-degrading enzymes.
- Researchers from Novara, Italy, presented data at the 29th European Academy of Dermatology and Venereology (EADV) Congress, EADV Virtual, indicating that nicotinamide may protect skin cells from the damaging effects of ultraviolet radiation. Their findings indicate that pretreatment with nicotinamide protects human skin cells from UVB-induced damage by increasing DNA repair, lowering reactive oxygen species generation, lowering nitric oxide release, and inhibiting local inflammation. The most dramatic effect of pre-treatment with nicotinamide occurred one day before to UVB exposure.
3. NAD+ Rejuvenates Skin.
Chronic oxidative stress and inflammation in old age is a primary cause of NAD+ decrease. The use of NAD+ precursors to promote NAD+ anabolism may be a therapeutically meaningful treatment method for aging cells. Recent research has demonstrated that increasing NAD+ levels can help to mitigate global oxidative cell damage, refill total NAD+ storage, and restore normal skin cell function.
4. NAD+ Protects the DNA.
The importance of replenishing and sustaining cellular NAD+ levels has gained widespread acceptance as a result of recent scientific discoveries. A genome is an organism’s complete set of DNA, including all of its genes. To combat everyday genomic assaults, tissues with a high cellular turnover rate, such as the skin, require greater amounts of NAD+.
5. NAD+ Improves Skin Elasticity.
Scientists also researched that the NAD+ component itself has anti-aging skin health effects comparable to those of niacinamide, such as wrinkle reduction, collagen formation, and increased skin suppleness.
6. NAD+ Moisturizes and Prevents Transepidermal Water Loss.
It has been proven in research topical use of B3 lowers transepidermal water loss (TEWL) and enhances the stratum corneum’s moisture content.
7. Skin May Supply NAD+ to Other Cells.
Previously, it was discovered that during exercise, NAD+ levels drop while NADH levels rise. According to a study published in 2019, NADH levels increase in the skin while NAD+ levels drop. Skin cells at this level have an active NADH metabolism and respond dynamically to ischemia-induced hypoxia and later to reperfusion-induced reoxygenation of other cells.