Male infertility is common among people with diabetes because of issues with libido, erectile dysfunction, and sperm abnormalities. According to the International Diabetes Federation, type II diabetes is anticipated to impact approximately 10% of the world’s population by 2045.
Pioglitazone and metformin, two diabetes treatments, have shown promise in recovering sperm function in diabetic men, but more effective medicines and potential adjuvant therapies are needed to fully restore male fertility. But now new research has emerged supporting the role of NMN to reduce diabetes-related male infertility among mice models.
Liao and colleagues from the University of South China reveal in Acta Biochimica et Biophysica Sinica that administering nicotinamide mononucleotide (NMN) to diabetic male mice improves teste’s structure and function and increases the amount of viable sperm.
Treatment with NMN Reverses Testicular Dysfunction Caused by Diabetes.
Streptozotocin, a chemotherapeutic medication, was used to treat mice, and it is known to promote type II diabetes in mice due to its toxicity to pancreatic cells. Their diabetes mouse model displayed a dramatically reduced sperm count and a much greater proportion of abnormal sperm proving. Then with the treatment with NMN restored normal sperm quantity and restored the decreased sperm count seen in diabetic mice.
Specifically, Liao and coworkers measured the diameter of seminiferous tubules, which are found in the testes and are responsible for the development of sperm precursor cells (spermatozoa) to evaluate NMN’s potential to repair testicular integrity in diabetics. The mice with type II diabetes had significantly smaller seminiferous tubules in area and diameter compared to control mice, but NMN reversed these abnormalities.
(Ma et al., 2022 | ABBS) NMN treatment restores the size of sperm-generating tubes. Liao and coworkers investigated glycolytic enzymes in testes since impaired glycolysis is associated with type II diabetes. The enzyme levels in the testicles of diabetic mice were adjusted by NMN. According to these results, NMN restores glucose consumption in the testes of diabetic mice, which may provide the cellular energy required for sperm generation and perhaps repair male infertility.
Treatment for Male Infertility Caused by Diabetes
Men with diabetes may regain fertility if they use anti-diabetic drugs like pioglitazone or metformin because these drugs stimulate glycolysis in the testes. Research by Liao and coworkers suggests that NMN might be used as an alternative strategy to improve sperm count in males. Pioglitazone, metformin, and NMN have all been shown to improve sperm quality in men with diabetes, but future research should evaluate these three treatments to see which is most effective. Individuals with diabetes who are of childbearing age may soon have the opportunity to have children if NMN successfully recovers male fertility in those with diabetes.
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