Safety of NMN, Resveratrol and Spermidine in Pregnancy. What Research Says?

September 23, 2022

For both their own and their children’s sakes, many pregnant women make dietary changes during this special time. Concerns have been raised concerning the possible dangers of taking some nutritional supplements during pregnancy, and there is much-contradicting information about their safety and/or effectiveness. Here we will discuss the safety of NMN, Resveratrol, and Spermidine in pregnancy.

Resveratrol In Pregnancy:

There is mounting proof that resveratrol can help treat infertility caused by ovarian dysfunction, PCOS, or endometriosis in women. Despite the extensive research into resveratrol’s positive impacts on human health, little is known about the supplement’s potential impact on maternal and fetal metabolism when taken by pregnant women. Multiple studies demonstrate the high bioavailability and low toxicity of oral resveratrol.

One study explored resveratrol’s metabolic effects on obese pregnant women. After 60 days, 80 mg of resveratrol reduced Gestational Diabetes Mellitus and improved lipids and glucose. In animal studies, Resveratrol administration during pregnancy reduced maternal body weight, improved glucose tolerance, and increased blood flow volume in the uterine artery.

Source matters for resveratrol for pregnant and breastfeeding females. When consumed at the levels found in some foods, resveratrol is probably safe. The safe use of resveratrol during pregnancy has been documented in animal studies since it is able to cross the placenta. Its teratogenicity has not been ruled out; resveratrol should be avoided during the luteal phase (beginning) of pregnancy, especially in the shape of supplements. Moreover, wine should not be consumed during pregnancy or breastfeeding as a source of resveratrol.

Pregnant women are proven to tolerate resveratrol well.
It is better to find resveratrol from food-based sources rather than supplementing it.
Finding alcohol as a resveratrol source isn’t suggested.

NMN In Pregnancy:

It is widely agreed that nicotinamide adenine dinucleotide (NAD) is an important factor in all cells. NAD synthesis supports energy production, DNA repair, and cell communication.

Environmental and genetic factors can inhibit NAD production, causing a deficiency. A study found that this defect can be especially damaging during pregnancy, as it might impair an embryo as it develops. Researchers at the Victor Chang Cardiac Research Institute have found that increasing maternal intake of this nutrient may reduce the risk of miscarriages and congenital abnormalities in mice. Before this nutrient was added to mothers’ diets, embryos were miscarried, or babies were born with birth abnormalities. After the nutritional modification, all kids were born healthily and without miscarriages or birth abnormalities.

In another 2020 study focused on maternal ovulation decline with aging, taking NMN in vivo improved the maturation rate, fertilization success, and subsequent embryonic development potential of oocytes from maternally aged mice.

Safety studies of oral NMN supplements in healthy people for other concerns have been under study and clinical trials. However, there is an absence of data from human clinical trials and preclinical research supporting the safety of the NMN employed for pregnant females.

No human study has been yet done to prove the use of NMN in pregnancy or lactation.
In animal studies, NMN has been proven to reduce ovulation-related aging, reducing miscarriages and congenital abnormalities.

Spermidine in Pregnancy:

According to medical professionals, expecting or nursing mothers should not take spermidine supplements due to a lack of human studies that prove its usefulness for pregnant women. It has been studied that the concentration of spermidine in the blood rises throughout a healthy pregnancy, reducing the need for extra supplementation. That is why pregnant and breastfeeding women should avoid spermidine supplements. Children shouldn’t use it because they don’t require dietary supplements like spermidine.

There is no human evidence proving the use of spermidine in pregnancy as it is enough produced in the body to supplement the needs.

Women who are expecting should supplement their diets with the prenatal vitamins their doctors recommend. If you’re taking any sort of dietary supplement, you should know exactly what it is and why. Have a conversation with your doctor about the importance of prenatal vitamins.