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A Deep Dive into Resveratrol Effectiveness. When Shall One Expect the Results?

resveratrol effectiveness

Resveratrol has come to the forefront as a significant therapeutic option for increasing longevity, by slowing the aging process and warding off chronic diseases. Due to red wine being, the most abundant source of resveratrol, it is notably well-known for its involvement in the so-called “French Paradox” — how the French seems to have low heart disease mortality rates despite a diet heavy in butter and cream. In 2003, the media began referring to resveratrol as “The Red Wine Molecule” when it was shown to increase lifespan in obese male mice. The Polygonum cuspidatuman Asian plant, provides supplement extracts. 

According to reports, resveratrol effectiveness has been studied including antiangiogenic, immunomodulatory, antimicrobial, neurological, anticancer, antidiabetic, and cardiovascular diseases (CVD) prevention, it has garnered significant interest from medical chemists, diet nutritionists, and health professionals over the past few decades. Learn Scientific research about resveratrol benefits here.

resveratrol effects and benefits

Resveratrol effectiveness as an antiviral.

When everyone is concerned with Covid and boosting immune response by strengthening and consuming extra antivirals, antioxidants, and anti-inflammatory compounds, resveratrol also stands up to the challenge here. This natural bioflavonoid is all three of those characteristics by coincidence. Resveratrol has been shown in a 2015 study, to be effective against influenza, hepatitis C virus, respiratory syncytial virus, varicella-zoster, Epstein-Barr herpes simplex virus, HIV, African swine fever, enterovirus, human metapneumovirus, duck enteritis virus, and the virus used to induce multiple sclerosis in animal models. In practically all studies, resveratrol exhibited antiviral activity. Another 2022 research suggested that using resveratrol showed a decreased incidence of hospitalization, COVID-related ER visits, and pneumonia in outpatients with moderate COVID-19.

According to Dr. David Sinclair, “One hundred years from now, people will maybe be taking these molecules on a daily basis to prevent heart disease, stroke, and cancer

In this regard, taking resveratrol as a supplement is significantly superior.

What is the Effective Dosage?

Resveratrol is the subject of ongoing research, focusing on the ideal healthy dosage people need to receive its health benefits. According to clinical study data, resveratrol dosages between 20 mg and 2,000 mg per day are safe and well-tolerated. Another clinical study shows that ingesting up to 5,000 mg of resveratrol per day is safe, whereas above 2,500 mg may produce stomach adverse effects such as cramping, gas, and nausea.

Human trials have revealed the following effects with relevant dosages used in the studies.

  • 0.15mg /kg
It may be best for lowering blood pressure by making artery walls less stiff.
  • 25mg
Oral intake of this dose proved that this amount has zero bioavailability.
  • 75mg 
It was administered to type 2 diabetic patients with enhanced neurovascular coupling capability and better cognitive function.
  • 270mg
It was given to postmenopausal, overweight, and obese patients, which resulted in better flow-mediated dilatation.
  • 80mg – 282 mg
This dosage was administered resulting in an increase in mitochondrial capacity and activation of fat oxidation.
  • 250-500mg
This dosage resulted in improved cerebral blood flow in healthy people.
  • 450mg-1g 
Regular consumption has beneficial effects on health-related to oxidative stress and inflammation.
  • 500mg–5g
Forty healthy volunteers were given 500, 1000, 2500, and 5000 mg for 29 days, reducing cancer risk. 2500 mg / 2.5 g had the highest effect.
  • 5g
Patients with Friedreich ataxia who received resveratrol for 12 weeks had improvement in neurologic function, audiology, and speech measurements, as well as plasma oxidative stress marker levels.

Resveratrol Effectiveness Timeline

In humans, many of the molecular pathways responsible for resveratrol effectiveness are still being researched. But numerous research has examined the relationship between resveratrol’s health benefits and its dietary dosage.

48 hrs.: It was studied that 48 hours of exposure to 100 mM resveratrol caused human colorectal cancer cells to die. Another research suggested that resveratrol therapy for two days caused a significant reduction in cancer development.

2 weeks: After two and four weeks of resveratrol therapy, plasma resveratrol concentrations varied from 0.7 to 2.55 μM.

4 Weeks: After four weeks of resveratrol treatment, the total antioxidant capacity in the blood plasma samples increased significantly compared to those obtained at baseline.

30 days: A study indicated that 30 days of therapy with 150 mg/day of resveratrol resulted in better cellular and systemic metabolic parameters, such as enhanced mitochondrial respiration in the muscle and lowered circulating glucose and lipid levels.

3 months: It was studied in a 2016 study that resveratrol when administered in lesser doses over a shorter period, resveratrol benefited Non-alcoholic fatty liver disease patients (NAFLD). 300 mg resveratrol daily for 3 months lowered ALT and AST, enhanced lipid metabolism, and decreased inflammation and glucose levels. This study was also quoted by Dr. Sinclair in his posts. However higher dosages have the same effects as 500mg of resveratrol in liver disease cases and raised the liver enzymes. This means that the extra dosage didn’t have any significant changes in the effect. (1) (2)

Another study found that daily resveratrol administration for three months improved glycemic management by decreasing HbA1c levels, systolic blood pressure, total cholesterol, and total protein.

resveratrol effectiveness in liver studies

1 year: In studies resveratrol was administered to patients for one year and it was proposed that patients with mild to severe Alzheimer’s disease may safely take resveratrol proving it an effective treatment for Alzheimer’s. (1) (2)

For Diabetes: 

Duration Dosage Result
45 days 1g greatly decreased fasting blood glucose, sHbA1c, insulin, and insulin resistance. 
4 weeks 2× 5 mg Reduced oxidative stress and blood glucose, enhanced insulin sensitivity
4 weeks 480 mg enhanced periodontal health along with reducing insulin sensitivity 
60 days 50mg accelerated healing and size reduction of foot ulcers.
1-year 8mg with diet  Reduced blood levels of inflammatory markers IL6 and ALP, and decreased expression of inflammatory cytokines CCL3, IL-1, and TNF.
3 months 250 mg Improved hemoglobin A1c, systolic blood pressure, total cholesterol, and total protein
4 weeks 0, 75, 150, 300 mg Enhanced vasodilator function

For Cancers: 

It has been shown that resveratrol may overcome drug resistance in many types of cancer cells by sensitizing them to chemotherapeutic drugs. (1) Resveratrol effects were found for cancer in these human studies.

Duration Dosage Result
14 days 80 and 20 mg Reduced cancerous cells in colorectal cancer. 
14 days 5 grams  Increases the enzymatic activity helping in the reduction in proliferation of hepatic cancer
20 days 5 grams  reduces cancer spread in multiple myeloma patients 
12 weeks 10‐50 mg enhances the capability of the tumor suppressor gene for breast cancer. 
28 days 4.4‐35.2 µg Reduces the spread of borderline pancreatic cancer

Resveratrol Effects on Mental Health:

Besides many advantages for human aging and longevity, many intriguing health advantages have been connected to resveratrol supplementation, including safeguarding brain function.

  • Can Cross Blood-Brain Barrier: Studies have shown that it can pass the blood-brain barrier making it an effective treatment for brain-related conditions.
  • Reduces Anxiety and Depression: Research has proven that Resveratrol may raise DA and 5-HT in the prefrontal cortex and NPY in the brain, which helps fight depression. It has also been studied that it increases dopamine and serotonin. Thus, resveratrol is seen as a possible contender for the creation of anti-anxiety and anti-depressant drugs.
  • Increasing Blood Flow to Brain: resveratrol has been studied to increase cerebral blood flow, hypercapnia-induced vasodilator responsiveness, cognitive assessments, perceived performance, and A40 plasma and cerebrospinal fluid levels in humans, according to clinical data from randomized clinical studies.
  • Effective Stroke-Related Risk Factors: In a 2018 study, risk factors of stroke were kept under observation while giving doses of 100mg and 200 mg to a group of stroke participants. It was then proven that adding resveratrol to allopathic therapy improved all of the observed indicators, including those that serve as significant stroke risk factors.

For Heart Health/ Conditions: 

Due to its antioxidant characteristics, resveratrol might be a beneficial blood pressure-lowering substance. Resveratrol may have additional cardiovascular health-promoting characteristics.

Condition Duration Dosage Result
Healthy people  1 month 400 mg Significantly decreased expression of IL-8; decreased plasma IFN and fasting insulin levels.
Angina pectoris  2 months 20 mg Reduce C-Reactive Proteins 
Myocardial infarction 3 months  10 mg Improved diastolic and endothelial function of the left ventricle, reduced LDL

 

How much to take?

Clinical evidence is still going on and data is not much available on effective resveratrol effectiveness. When taken alone or in combination with other Phytomolecules in clinical studies, resveratrol has been shown to be safe at levels as high as 5 grams per day. In addition, 2 grams of resveratrol administered daily for 90 days was well tolerated by obese adults aged 70 or older.  The available clinical trials used normal dosages of resveratrol. Scientists utilized resveratrol at a dose of 150 mg/day for at least 30 days to study weight reduction and the longevity-promoting benefits of intermittent fasting. However, this should not be taken without first consulting a physician.

Dr. Sinclair suggests consuming at least 500 mg of resveratrol every morning, especially with a fat source as it’s not water-soluble also (to improve absorption by up to 5x). Sinclair obtains his fat from yogurt. David’s daily dosage is 1g (1000 mg), taken in the morning.

Note that resveratrol is known to have drug interactions; check out this article here.

As always, consult your doctor before adding or subtracting any food, supplementation or drug.

 

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