NMN is most effective when taken in the morning and can be ingested with water or food. NMN, boosting NAD+, has an impact on the circadian rhythm – the ingestion of NMN supplement should happen during the day and within six hours after being awake.

Bioavailability of resveratrol is higher on an empty stomach (8 hours of fasting) and when taken in the morning due to the influence of the circadian rhythm.

Spermidine is most effective when taken in the morning at the same time every day and recommended to ingest along with food to enhance their absorption .

As a David Sinclair, the longevity genetic expert and Harvard professor, has been using NMN over a decade. He dissolves the white powder form of NMN and resveratrol in either Greek yogurt or organic cold press olive oil before ingestion every morning.

Rescence Laboratory team unanimously prefers a tasty savory treat dissolving the Rescence Pure NMN and Pure Resveratrol in a teaspoon of organic cold press olive oil and a bit of balsamic vinegar first thing in the morning, in their salad (for those who are not doing intermittent fasting!)

The suggested dose for adults between the ages of 30 and 60, based on the results of effectiveness and safety studies in humans and animals, as well as calculations of optimal NMN doses, is 500 mg per day. People over the age of 65 can safely take 750 mg of NMN per day to get the most out of the supplement.

NMN to Support Skin Health: Study indicated that 250–300 mg of NMN per day may help protect and heal sun-damaged skin.

NMN to Improve Muscular Function: A study found that taking 250 mg of NMN daily for 12 weeks improves muscular function in males over 65. The same dosage for 10 weeks also showed an increment in insulin sensitivity and women’s muscles.

NMN to Uphold Cardiovascular Health: Researchers are conducting a clinical trial to determine the effect of NMN on cardiovascular and metabolic health when given 250 mg daily.

NMN to Support Fertility: A study demonstrated that a low dose of 350 mg per day in a 50 kg person NMN restored fertility, more than 1,400 mg per day did not demonstrate benefit, suggesting an appropriate human dosage is between 350 mg to 1,500 mg per day.

NMN to Boost Metabolism: According to the results of scientific research , 1,000 mg of oral NMN supplement per day can enhance NAD+ metabolism in healthy middle-aged and older individuals.

Renowned anti-aging genetic research Harvard professor Dr. David Sinclair has said in a recent interview that he himself takes powder form 1,000 mg of NMN daily in addition to 1,000 mg of resveratrol without seeing any harmful effects for over a decade.

NMN’s safety and efficacy are also being investigated in other clinical trials registered with the World Health Organization (WHO).

There are no definitive studies demonstrating that NMN has adverse effects at regularly used levels (up to 1,000 mg per day), and the elevated NAM associated with such concentrations is unlikely to pose a substantial health concern.

It is prudent to avoid doses of more than 1,000 mg per day if using oral capsules, as these dosages result in significant increases in NAM and may create methylation problems for certain individuals.

The bioavailability and pharmacokinetics of resveratrol depend on the doses ingested, the concomitant ingestion of food matrix, the particle size, the gut microbiota, and the circadian variation. Check out this article about the dosage.

The research findings suggest that a repeated and moderate administration of resveratrol is better than the administration of a single, higher dose. A safe and efficient dose is 1,000 mg (1 g) up to 5 g per day.

Professor of anti-aging genetics at Harvard, Dr. David Sinclair, stated in a recent interview that he takes 1 mg of spermidine on a regular basis.

Spermidine for hair growth. The study indicated that spermidine supplementation of 0.5 mg can support hair growth and strength.

Spermidine for cardiovascular health. According to a research, use of spermidine supplement of 4 mg/daily for 8 weeks reduces the risk of hypertension, heart failure, and other cardiovascular issues.

Spermidine to support cognitive function. A study indicates that the dosage of 1.2 mg of spermidine for 3 months reduced age-related cognitive decline and risk of Alzheimer’s.

Spermidine to slow down aging. One study found a connection between higher spermidine consumption from dietary sources such as supplements and improved human survival rates.

Spermidine for post covid vaccination. Another current human study uses proven ways to investigate if older people may safely take a daily spermidine supplement after having a SARS-CoV-2 booster injection.

NMN supplement was shown safe without any side effect with up to 1200 mg per day for 6 weeks – 10 male and 2 female amateur runners between 27 and 50 years old, reported no obvious side effect.

People who have used NMN supplements have not yet experienced any substantial negative side effects of taking NMN, which is a positive development.

Not enough studies are conducted on humans in preventing or suppressing cancer cells. It is always advised to consult physicians prior to taking any supplements. 

Resveratrol is well tolerated and generally considered safe without toxic side effects up to 5 grams. Everyone may experience different adverse effects if any. Check out this article for findings on the side effects.

Always consult with your physician before adding or removing any supplement.

Because spermidine occurs naturally in the human body, it is believed to be fully safe. Researches have proven that the supplement has no negative side effects. 

In accordance with Section 20l(s) of the Federal Food, Drug, and Cosmetic Act, the FDA has determined that spermidine-rich wheat germ extract is Generally Recognized As Safe (GRAS).