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Cis-Resveratrol or Trans-Resveratrol, Which One Is Better?

An image showing the chemical structure of trans-resveratrol

Types Of Resveratrol: Trans-Resveratrol versus Cis-Resveratrol

Resveratrol , a natural polyphenol, has shown significant antioxidant capacity as a natural dietary element.

In nature, there are two distinct isomeric forms of resveratrol, cis-resveratrol and trans-resveratrol. Cis-Resveratrol is the double bond isomer of trans-resveratrol, the more researched and naturally occurring isomer of resveratrol. By virtue of its structure, the trans-form of resveratrol is known to have estrogenic action. The cis-form of resveratrol is unstable, and it transforms into the trans-form when exposed to ultraviolet radiation. Trans-resveratrol stands out from cis-resveratrol owing to its stability, prevalence, and strong biological activity in initiating cellular responses such as cell cycle arrest, differentiation, apoptosis, and boosting cancer cells’ anti-proliferation. So, the more physiologically active isomer is trans-resveratrol.

Why is Trans-Resveratrol Is More Efficient?

Trans-resveratrol as the active element in resveratrol supplements yields potential health benefits possibly due to its structural features. The backbone of trans-resveratrol is planar, whereas the backbone of cis-resveratrol has two primary planes. Resveratrol especially trans-resveratrol may have a variety of physiological effects, including the expansion of blood arteries and the reduction of blood clotting. Additionally, it may alleviate pain and swelling, lower blood sugar levels, and aid the body in fighting disease.

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